Clinical use of monoclonal antibody.

Monoclonal antibody use in inflammatory bowel disease.

Christopher E. Hayes, MD, and Carolina S. Cerezo, MD  CrohN’s disease (Cd), ulCeraTive ColiTis (UC) and indeterminate colitis (IC) are chronic inflammatory bowel conditions usually collectively referred to as inflammatory bowel disease (IBD). They appear to be the result of the interaction of genetics, the environment and microbiome of the gastrointestinal tract. The common pathway to intestin...

Development of a Novel Inhibitory Chimeric Anti-HER2 Monoclonal Antibody

Ofatumumab Monoclonal Antibody Affinity Maturation Through in silico Modeling

Background: Ofatumumab, an anti-CD20 mAb, was approved in 2009 for the treatment of chronic lymphocytic leukemia. This mAb acts through immune-mediated mechanisms, in particular complement-dependent cytotoxicity and antibody-dependent cellular cytotoxicity by natural killer cells as well as antibody-dependent phagocytosis by macrophages. Apoptosis induction is another mechanism of this antibody...

Anaphylaxis: implications of monoclonal antibody use in oncology.

Anaphylaxis is currently classified as an immunologically triggered response with reactions that are IgE-mediated and reactions that are not IgE-mediated. This immunologically mediated phenomenon can result in various clinical manifestations, including decreased blood pressure, generalized skin inflammation, such as hives and pruritus, and respiratory symptoms, such as wheezing or bronchospasm....

production of monoclonal antibody against alkylhydroperoxide reductase

development of a stool antigen immunoassay to detect helicobacter pylori infection requires monoclonal antibody against the specific antigen. alkylhydroperoxide reductase (ahpc) of helicobacter pylori has been described as a specific and unique enzyme for h. pylori and therefore, both h. pylori ahpc and anti-ahpc could be useful in the development of serologic and stool antigen tests, for detec...